Substrate AI provides AI Native Revenue Cycle Management (RCM) software that autonomously completes mission-critical tasks in healthcare revenue cycle such as claim status, appeals, policy reviews, payment posting, refunds, and more. Their agents connect to healthcare systems and run accounts receivable autonomously from claim status and appeals to payment posting and refunds. The software integrates with PM, EHR, and clearinghouse systems without migration and is live within 48 hours for most practices. It offers features like full audit trail, human-in-the-loop escalation for uncertain cases, predictive insights on payer trends and denial patterns, eligibility checks, payer policy review, document review automation, and tailored automation pipelines built by AI engineers embedded with client teams. The platform emphasizes security with end-to-end encryption, zero-trust architecture, periodic security audits, granular access controls, and compliance with HIPAA and SOC2.